Effects of a number of classes of 50S inhibitors on stop codon readthrough during protein synthesis.
نویسندگان
چکیده
The effect of a number of antibiotics on stop codon readthrough during protein synthesis in Escherichia coli was examined. Inhibitors which bind close to the entrance of the peptide exit tunnel on the 50S ribosomal subunit promote substantial levels of readthrough, presumably by disrupting the mechanism of peptide release.
منابع مشابه
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 48 12 شماره
صفحات -
تاریخ انتشار 2004